Sunday, June 23, 2024

Sunday UDLC journal club: Efficacy of nano knife v radio frequency ablation

UDLCO summary:


A patient of liver carcinoma contemplating further intervention through removal of pathology using a nano knife seeks help in the group from other users. A quick summary of it's efficacy with respect to radio frequency ablation comparators are shared. Further journal club search and shares and further deidentified patient history details welcome to actually assess the patient's real requirements in terms of tumor debulking and expected "real" cure on longer follow up.


[23/06, 13:20] Indian Health IT Prof: Wanted some information on 2 areas for a terminal patient with HCC 1. Are there any teleradiology services where the patient can take a second opinion, they have 2 reports ct scan which are slightly conflicting 2. Any info about nanoknife or cyberknife? Apparently medanta is doing it ?


[23/06, 13:24] Indian Health IT Prof: https://www.youtube.com/watch?v=qhxSsGpf4J4


[23/06, 13:31] BLLM: Doesn't look better than radio frequency 
ablation👇

"152 patients with malignant liver tumors were randomized into nano knife intervention aka IRE (n = 78) and radio frequency ablation RFA (n = 74) groups. 

The primary endpoint was the success rate of tumor ablation; the secondary endpoints included the tumor ablation time, complications, tumor recurrence rates and treatment-related adverse events (TRAE).

The success rate of tumor ablation using IRE was 94.9% and was non-inferior to the RFA group (96.0%) (P = 0.761). 

For the secondary endpoints, the average ablation time was 34.29 ± 30.38 min for the IRE group, which was significantly longer than for the RFA group (19.91 ± 16.08 min) (P < 0.001). 

The recurrence rates of liver tumor at 1, 3 and 6 months after ablation were 0 (0.0%), 10 (13.9%) and 10 (13.3%) in the IRE group and 2.9%, 7.3% and 19.7% in the RFA control group (all P > 0.05), respectively. 

Unquote



CC licence: https://commons.m.wikimedia.org/wiki/File:Nanoknife.jpg#mw-jump-to-license

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